Study objective was to assess the impact of complementary feeding bottles given at maternity hospital and/or over the first month after discharge from the maternity ward on cow’s milk allergy (CMA) risk in breastfed infants…
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Single-cell RNA sequencing (scRNA-seq) revolutionized our understanding of disease biology. The promise it presents to also transform translational research requires highly standardized and robust software workflows. Here, we present the toolkit Besca, which streamlines …
Individual diet components and specific dietary regimens have been shown to impact the gut microbiome.In this study, we explored the contribution of long-term diet by searching for dietary patterns that would best associate with the gut microbiome in a population-based cohort.
New Caledonia is a Pacific island of 270,000 inhabitants with mixed ethnicities, including Polynesians (10.2%), people from European ancestry (27.2%), and Melanesians (39.1%),. This study aimed at determining the prevalence of gout and hyperuricemia in the general population and the various ethnicities of New Caledonia.
Lipopolysaccharide (LPS) and monophosphoryl lipid A (MPLA) induce, overall, similar transcriptional profiles in healthy individuals, although LPS has been shown to more potently induce pro-inflammatory cytokines. We explore herein whether MPLA could be considered as a synthetic replacement of LPS in immune functional assays to study anergy of immune cells in septic patients.
We hypothesize that chondrocytes from the deepest articular cartilage layer are pivotal in maintaining cartilage integrity and that the modification of their prehypertrophic phenotype to a hypertrophic phenotype will drive cartilage degradation in osteoarthritis.
Environmental exposure chambers (EECs) have been used extensively to study allergic rhinoconjunctivitis. Few studies have been published using EECs in conjunctivitis only, and none have used conjunctival allergen challenge as a selection criterion…
Les technologies numériques permettent de faciliter le recueil d’information de santé et de nutrition par les participants aux études cliniques. Cependant, l’appétence à ces technologies est généralement évaluée en population générale, auprès de patients…
Angiogenesis is a key process in tumor growth and metastasis, as adequate vasculature and blood supply ensures tumor growth and development [1]. In normal tissues, blood vessel growth is usually kept to a minimum, and angiogenesis is regulated by a balance…
Angiogenesis is a key process in tumor growth and metastasis, as adequate vasculature and blood supply ensures tumor growth and development [1]. In normal tissues, blood vessel growth is usually kept to a minimum, and angiogenesis is regulated by a balance…
The Pneumo-Quest self-questionnaire was developed to standardize the practice of recollection when welcoming a new patient. It consists of 82 main questions and 34 subsidiary questions to be completed at home by the patients before their first visit to a pulmonologist. This evaluation was carried out on the basis of 137 returned questionnaires.
The complexity of sepsis pathophysiology hinders patient management and therapeutic decisions. In this proof-of-concept study we characterised the underlying host immune response alterations using a standardised immune functional assay (IFA) in order to stratify a sepsis population.
Objectives: Hydroxychloroquine (HCQ) is an anchor drug in the treatment of systemic lupus erythe-matosus (SLE). Adherence to HCQ is key for efficacy. Inaccurate evaluation of adherence could lead tonon-justified switch to more expensive or less tolerated drugs.
Initial combination therapy plays a central role in managing pulmonary arterial hypertension (PAH) [1–4]. Patients with low- or intermediate-risk of 1-year mortality at diagnosis should be
Immunoglobulins are 2nd or 3rd-line treatments in dermatomyositis (DM) or polymyositis (PM) refractory to high-dose corticosteroids and immunosup…
Systemic lupus erythematosus (SLE) is a chronic autoimmune multi-organ disease with an unpredictable course. SLE causes functional disability, …
Recent advances in the immunotherapy field require evaluation of the immune function to adapt therapeutic decisions.
Evaluation of serum thymidine kinase 1 activity as a biomarker for treatment effectiveness and prediction of relapse in dogs with non-Hodgkin lymphoma.
Septic shock patients exhibit an increased incidence of viral reactivation. Precise timing of such reactivation-as an early marker of immune suppression, or as a consequence of the later-is not known precisely…
Methotrexate (MTX) is a remarkable drug with a key role in the management of rheumatoid arthritis (RA) at every stage of its evolution. Its attributes include good overall efficacy for signs and symptoms, inhibition of structural damage and preservation of function with acceptable and manageable safety…
Immune reconstitution after haematopoietic stem cell transplantation (HSCT) is a complex and dynamic process, varying from a state of nearly complete immunosuppression to an expected full immune recovery…
Immunoglobulin replacement therapy (IgRT) is increasingly used in secondary immunodeficiency (SID) related to hematological malignancies (HM) to prevent infections…
In efficacy trials of a tetravalent dengue vaccine (CYD-TDV), excess hospitalizations for dengue were observed among vaccine recipients 2 to 5 years …
Subcutaneous immunoglobulin replacement therapy (IgRT) may be administered once a week with a pump or every other day with a syringe (rapid push)…
Pre-capillary pulmonary hypertension (PH) in systemic sclerosis (SSc) is a heterogeneous condition with an overall bad prognosis. The objective of this…
The uric acid (UA) level in patients with gout is a key factor in disease management and is typically measured in the laboratory using plasma samples…
To describe the characteristics of patients suffering from secondary immunodeficiencies (SID) associated with hematological malignancies (HM), who …
Patients with primary immunodeficiency (PID) often receive immunoglobulin replacement therapy (IgRT). Physicians…
Analysing correlations between the observed health effects of ingested probiotics and their survival in digestive tract allows adapting their…
We assessed antibody persistence following booster vaccination with a Japanese encephalitis chimeric virus vaccine (JE-CV; IMOJEV) in …
Basophil activation contributes to inflammatory reactions, especially in allergy. It is controlled, positively and negatively, by several mechanisms. High-affinity IgE receptors (FcεRI) generate a mixture of activation and inhibition si…
The human protease family HtrA is responsible for preventing protein misfolding and mislocalization, and a key player in several cellular processes…
Pulmonary arterial hypertension (PAH) is a rare complication of systemic lupus erythematosus (SLE)…
In real life, in a substantial proportion of gouty patients receiving urate-lowering therapy (ULT), urate levels are not maintained below the target…
To assess quality of life and satisfaction regarding immunoglobulin-replacement therapy (IgRT) treatment according to the route (intravenous Ig [IVIg] or…
Clofibrate is a known rodent hepatotoxicant classically associated with hepatocellular hypertrophy and increased serum activities of cellular alanine aminotransferase/aspartate aminotransferase (ALT/AST) in the absence of microscopic hepatocellular degeneration.
Ischemic digital ulcers (DU) represent a major complication of systemic sclerosis (SSc). We investigated the impact of controlling the ulcerative disease on disability, pain, and quality of life in SSc patients receiving bosentan.
The supine sleeping position with the head higher than the legs has no impact on regurgitations in infants. Inclined ventral decubitus decreases regurgitations but is associated with an increased risk of sudden infant death syndrome (SIDS). The LUNE study aimed to evaluate the impact of regurgitations on the choice of sleeping position by pediatricians and parents.
The microbiota controls a variety of biological functions, including immunity, and alterations of the microbiota in early life are associated with a higher risk of developing allergies later in life.
IgG replacement therapy (IgRT) in primary immunodeficiencies (PID) is a lifelong treatment which may be administered intravenously (IVIg) or subcutaneously (SCIg), at hospital or at home. The objective of the VISAGE study was to investigate if route and/or place for IgRT impact patients’ satisfaction regarding IgRT and quality of life (QoL) in real-life conditions.
Snapshot on epilepsy in patients referred to tertiary centers and discloses needs for diagnosis and treatment.
The aim of this study was to assess health-related quality of life in patients with pulmonary arterial hypertension associated with CHD and correlations with clinical status.
Despite the wide use of the 6 min walk distance (6MWD), no study has ever assessed its validity as a surrogate marker for haemodynamics and predictor of outcome in isolated pulmonary arterial hypertension associated with systemic sclerosis (SSc-PAH). We designed this work to address this issue.
To estimate adult gout prevalence in France.
To estimate adult gout prevalence in France.
This prospective, multicentre, observational study assessed usability and utility (co-primary endpoints) of the consistency in r-hFSH starting doses for individualized treatment (CONSORT) calculator in French routine clinical practice.
To assess the effect of sildenafil, a phosphodiesterase type 5 inhibitor, on digital ulcer (DU) healing in systemic sclerosis (SSc)…
The aim of the study was to validate the French language version of the AR-PBI and to assess the treatment-related expectations and benefits provided in…
The aim of this study was to assess the prognostic value of systolic pulmonary artery pressure (sPAP) estimated by echocardiography in the multinational…
This study aimed to finalize and psychometrically validate the Satisfaction for PAtients in Crohn’s diseasE Questionnaire (SPACE-Q(©)), developed to…
The Test Your Memory (TYM) test has been proposed for screening dementia…
Ischemic digital ulcers (DU) are frequent and severe complications of systemic sclerosis (SSc). The purpose of our study was to assess the effect of DU..
The objective of this study was to modify the EVAPIL, a questionnaire designed to assess user-reported tolerability of combined oral contraceptives…
In France, the prevalence of gout is currently unknown. We aimed to design a questionnaire to detect gout that would be suitable for use in a telephone…
Ischaemic digital ulcers (DUs) are a common complication of systemic sclerosis (SSc). This study aimed to characterize patients with SSc and ongoing DUs…
The risk of serious bacterial infectious events (SIEs) after an RTX course used in severe and refractory cases of systemic autoimmune diseases (SAID) is…
The reciprocal links between comorbidities and gout are complex. We used cluster analysis to attempt to identify different phenotypes on the basis of…
To determine how cardiologists manage medical treatment in HF patients after hospital discharge, according to LVEF…
To assess the survival and prognostic factors in patients with newly diagnosed incident systemic sclerosis (SSc)-associated pulmonary arterial…
This study aimed to evaluate prospectively PCC use in patients with VKA-related bleeding in view of the French guidelines published in 2008…
Vitamin D could play a protective role in multiple sclerosis…
Prediction of pulmonary hypertension related to systemic sclerosis by an index based on simple clinical observations…
Pulmonary arterial hypertension (PAH) is a severe, life-limiting complication of systemic sclerosis (SSc). Guidelines recommend early detection and…
The prevalence and characteristics of pulmonary hypertension in adults with sickle cell disease have not been clearly established…
The objectives of this study were to compare the survival of patients with ILD-associated PH (PH-ILD) or pulmonary arterial hypertension (PAH) and to…
Systemic sclerosis (ScS) is very heterogeneous in its clinical presentation and its therapeutic care is not codified. A better knowledge of the patients…
The aim of the study was to assess the prevalence and characteristics of vertebral fractures in a cohort of adult patients with GD1…
Gaucher disease (GD), the most prevalent inherited lysosomal storage disorder, is caused by deficient glucocerebrosidase activity. Type 1 GD (GD1), the…
To characterize the epidemiology, management and impact on quality of life and outcome of paediatric pulmonary arterial hypertension, excluding…
To describe the history of SSc-associated pulmonary arterial hypertension (SSc-PAH) in patients with New York Heart Association (NYHA) functional class…
The EVAPIL scale is a self-questionnaire aimed to assess tolerability of oral contraceptives (OC)…
Digital ulcers are the most frequent vascular manifestations of systemic sclerosis (SSc). Clinical features of patients with prior or current digital…
The aim of this observational study was to investigate the incidence of PAH and pulmonary hypertension (PH) during a 3-year followup of patients from the…
This study identified and investigated a subset of SSc patients with early-onset PAH…
Gaucher disease and monoclonal gammopathy: a report of 17 cases and impact of therapy…
Prognostic factors for unfavorable clinical outcome in patients with heparin-induced thrombocytopenia (HIT) are largely unknown…
The aim of the Eclat survey was to evaluate the frequency of frailty in uncontrolled hypertensives and to individualize different frailty profiles…
To evaluate the efficacy and tolerability of a single intraarticular (IA) injection of hyaluronic acid (HA) for the treatment of hip osteoarthritis (OA)…
This longitudinal study investigated survival, risk factors and causes of death in the multicentre ItinérAIR-Sclérodermie cohort of patients with SSc…
The aim of the Impact-Reco programme was to analyse prescription rates of CHF drugs in stable outpatients with CHF related to left ventricular (LV)…
The purpose of this research was to review the literature on masked hypertension. Studies, reviews and editorials on masked hypertension were identified…
To determine prescription rates of CHF drugs, and to assess predictive factors for drug prescription using data from a large panel of French…
To describe the natural history of ischemic digital ulcers (DU) in systemic sclerosis (SSc)…
To establish the current prevalence of PAH in a large HIV-positive population…
To describe, according to the type of first-line antihypertensive monotherapy (FLAM) the persistence rate and the cumulative probability of its potential…
The purpose of this study was to compare the history of previous appendectomy and smoking habits in a group of patients with UC and a control group…
The aims of this study were to prospectively screen for PAH and to describe echocardiographic parameters in a large group of SSc patients…
The aim of this work is to better define the clinical profile of masked hypertensives within a population with controlled office blood pressure (BP) and…
To evaluate the prevalence and reproducibility of MH after excluding confusing factors [method and time of blood pressure (BP) measurement, …
The GRECO study has collected data on pregnancies, regardless of their outcome, that occurred in women taking an oral contraceptive…
We tried to determine the prognostic impact of triple (antiplatelet agents, statins and beta-blockers) and quadruple (the same+ACE inhibitors)…
The in-hospital management and short- and long-term outcomes was assessed in 2 registries of consecutive patients admitted for acute myocardial…
To assess whether patients discharged on combined secondary prevention medications after acute myocardial infarction (AMI) have improved 1-year survival…
Screening allows for early management of pulmonary arterial hypertension (PAH), a severe complication of systemic sclerosis (SSc). Since no consensus has…
To test the hypothesis that at least one part of the prevalence of MH would be an artefact due to the difference between the methods of measurements…
To compare compliance in type 2 diabetic patients treated with glimepiride once daily or glibenclamide twice to three times daily…
The objective was to evaluate in the SHEAF study the influence of the number of office or home blood pressure measurements on the classification of…
To assess actual practices and in-hospital outcome of patients with acute myocardial infarction on a nationwide scale…
To evaluate and compare the efficacy and safety of lercanidipine according to age…
We assessed the in-hospital management and short- and long-term outcomes of two series of patients admitted for acute myocardial infarction, 5 years…
To assess the prognostic value of home vs office BP measurement by general practitioners in a European population of elderly patients being treated for…
Handipark, a new score for measuring the impact of Parkinson’s disease on daily life activities is presented…
To compare management and short-term outcome of diabetic and non-diabetic patients hospitalized for acute myocardial infarction…
To evaluate in France in 2001 the therapeutic management and control of diabetes and of modifiable cardiovascular risk factors in patients with type 2…
ThA 90-day, multicenter, randomized, double-blind, parallel-group study was conducted to compare the efficacy of amlodipine (once a day) with nicardipine…
This study compared the efficacy and safety of nebulized corticosteroids in paediatric patients with severe persistent asthma…
To compare the efficacy of moxonidine (0.2 mg od) and rilmenidine (1 mg od), two selective I1 receptor agonists…
Assessment of acute blood pressure variability during a stress test…
To assess hypertension management and blood pressure control in patients with type 2 diabetes in France…
The objective of the present work is to describe the baseline data of the population enrolled in the SHEAF study with special emphasis on blood pressure…
The objective of this present work is to describe the baseline characteristics of the treated patients in the SHEAF study from February 1998 to March…
The goal of the SHEAF study is to determine whether self blood pressure measurement (SBPM) has a better cardiovascular prognostic value than office blood…
Acne is the most common symptom prompting patients to consult a dermatologist. No previous study has been conducted in France to determine the prevalence…
The objective of this study was to evaluate the impact of smoking habits on safety of trandolapril assessed by interrogation and by visual analogue…
The objective was to compare the compliance of hypertensive patients treated with captopril twice daily or trandolapril once daily…
The calibration of several ions (Cl(-), Br(-), F(-) and OH(-)) measured with an ion selective electrodes (ISE) array has been carried out in the presence…
The aim of this work was to analyze the different methods used for achieving induction of labor and their implications…
The objective of this study was to test the influence of bisoprolol and verapamil on left ventricular filling in hypertensive patients in a 6 month…
Different acne gradings have been proposed: global grading, semi-global grading, quantitative grading and photographic grading. They are mainly used in…
The aim of this double-blind randomized study was to compare the antihypertensive effects of trandolapril and nitrendipine in the elderly…
To investigate the effect of bisoprolol (B) and ramipril (R) treatment (TT) on the short-term variability of systolic blood pressure (SBP) diastolic…
In order to determine the different ways the hypertensives’ blood pressure would react during mental stress, 49 patients, 27 women and 22 men, were…
To study the modifications of the BP and its short-term variability in hypertensives patients submitted at to a psychological stress test…
The effectiveness and safety of cicletanine hydrochloride, the first representative of the furopyridine family, were evaluated in a 90-day double-blind…
The effects of cicletanine hydrochloride on glucose tolerance parameters were studied in a two-phase trial in which patients received a placebo for 2…
Efficacy and tolerance of cicletanine, the first derivative of furopyridines have been studied in a 3 parallel groups double blind study; 120 essential…
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